|
Non-Small Cell Lung Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Surgically-resected stage I-III NSCLC specimens (N = 100) were stained by immunohistochemistry (IHC) for the following immune markers: OX-40, PD-L1, PD-1, CD3, CD4, CD8, CD45RO, CD57, CD68, FOXP3, granzyme B, and ICOS.
|
31843013 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Irradiated aortic valve show similar (low) degrees of late T and B lymphocyte infiltration as control valves, whereas macrophage marker CD68 was decreased after radiotherapy for breast cancer.
|
31837504 |
2020 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Irradiated aortic valve show similar (low) degrees of late T and B lymphocyte infiltration as control valves, whereas macrophage marker CD68 was decreased after radiotherapy for breast cancer.
|
31837504 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This includes members of the Tumor Associated Macrophage family (CD68, CXCL5, and MARCO), members of the CT antigen family (PRAME, TTK and PBK) and the "second generation" checkpoints TIM3 and BTLA.
|
31831392 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We collected tumour tissue and clinical data from 57 PCNS-DLBCL and used immunohistochemistry to examine TAMs (CD68, CD163), TILs (CD3, CD4, CD8, PD1) and tumour B cells (PAX5/PDL1 double stains, PDL1).
|
31811434 |
2019 |
|
Indeterminate dendritic cell tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Diffuse dermal infiltration of a mixture of histiocytes and lymphocytes accompanied with multinuclear giant cells, the positive CD68 and Factor XIIIa and negative Langerin immunoreactions, along with the positive staining with CD1a and S100, led us to the diagnosis of ICH.
|
31789127 |
2020 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Distant metastasis was also associated with the eosinophil infiltration (P = 0.006); Stromal, intratumoral, invasive-margin, squamous intraepithelial lesion (SIL), and perivascular tumor-infiltrating lymphocytes (TILs); CD68+, CD163+, and CD204+ macrophage infiltration.
|
31776057 |
2020 |
|
Squamous intraepithelial lesion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Distant metastasis was also associated with the eosinophil infiltration (P = 0.006); Stromal, intratumoral, invasive-margin, squamous intraepithelial lesion (SIL), and perivascular tumor-infiltrating lymphocytes (TILs); CD68+, CD163+, and CD204+ macrophage infiltration.
|
31776057 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immune analyses indicated that pembrolizumab anti-programmed cell death 1 (PD-1) monotherapy alone can't induce effector immunologic response in most GBM patients, probably owing to a scarcity of T cells within the tumor microenvironment and a CD68+ macrophage preponderance.
|
31755915 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Patients with clinical evidence of drug response (lowered heart rate and blood pressure) demonstrated elevated tumor infiltration of CD68+ macrophages and CD8+ T cells.
|
31754048 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The amounts of TAMs (CD163+ and CD68+) and tumor HA were determined by immunohistochemistry.
|
31720917 |
2020 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Superoxide generation rate, activity of complex I in electron transport chain of mitochondria, activity of matrix metalloproteinase (MMP-2 and 9) of adipose tissues (AT) of patients with gastric cancer in AT located adjacent to tumor (ATAT) and at a distance of 3 cm (ATD) are measured to follow the connection of the redox state with some of the microenvironment indicators (HIF-1α, CD68, Plin5), body mass index (BMI) and cancer metastasis.
|
31711773 |
2020 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
Superoxide generation rate, activity of complex I in electron transport chain of mitochondria, activity of matrix metalloproteinase (MMP-2 and 9) of adipose tissues (AT) of patients with gastric cancer in AT located adjacent to tumor (ATAT) and at a distance of 3 cm (ATD) are measured to follow the connection of the redox state with some of the microenvironment indicators (HIF-1α, CD68, Plin5), body mass index (BMI) and cancer metastasis.
|
31711773 |
2020 |
|
Neoplasm Metastasis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
M1 is also characterized by the increased values of HIF-1α+ (factor 1.25), CD68+ (factor 1.4) and Plin5+ (factor 2.1) compared to M0 category in tumor tissues (p < 0.05).
|
31711773 |
2020 |
|
Secondary Neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
M1 is also characterized by the increased values of HIF-1α+ (factor 1.25), CD68+ (factor 1.4) and Plin5+ (factor 2.1) compared to M0 category in tumor tissues (p < 0.05).
|
31711773 |
2020 |
|
Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In an independent cohort, we confirmed that RSK1<sup>hi</sup> GBMs exclude long survivors, and RSK1 expression was associated with high protein levels of the mesenchymal subtype marker lysosomal protein transmembrane 5, as well as with high expression of CD68, which indicated the presence of infiltrating immune cells.
|
31701625 |
2020 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that high CD68 or high CD163 expression was correlated with clinicopathological characteristics, high CD163 expression was an adverse predictor for both overall survival (OS) [hazard ratio (HR) = 2.265, P = 0.005] and progression- free survival (PFS) (HR = 1.925, P = 0.017) in patients with DLBCL.
|
31694577 |
2019 |
|
Squamous cell carcinoma of skin
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
On the contrary there was no difference in CD3+, CD8+, CD20+, CD68+ expression when comparing cSCC in patients with recessive dystrophic epidermolysis bullosa to cSCC in renal transplant recipients .
|
31692111 |
2019 |
|
Hallopeau-Siemens Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
On the contrary there was no difference in CD3+, CD8+, CD20+, CD68+ expression when comparing cSCC in patients with recessive dystrophic epidermolysis bullosa to cSCC in renal transplant recipients .
|
31692111 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry demonstrated many CD68-positive macrophages around the tumor nests.
|
31677179 |
2020 |
|
Immune thrombocytopenic purpura
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared with vehicle (phosphate-buffered saline), thalidomide significantly inhibited the secretion of IFN-γ and IL-17 in ITP mouse and reduced the expression of CD68 in spleen.
|
31670229 |
2019 |
|
Hypothyroidism
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, there was an intralobular inflammatory reaction associated with significant (p<0.05) increases in the density of resident hepatic macrophages [cluster of differentiation 68 (CD68)+ cells], as well as in activated hepatic stellate cells, alpha-smooth muscle actin (α-SMA) index in livers with hypothyroidism.
|
31658321 |
2019 |
|
Endometriosis of uterus
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using the classical histological technique (Hematoxylin-Eosin), we identified the glandular structures; utilizing immunohistochemistry, we have labeled the endometrial epithelium with the anti-cytokeratin 7 (CK7) antibody and we analyzed the periglandular cell types of the immune system: T-lymphocytes using anti-cluster of differentiation (CD) 3 antibody, macrophages using anti-CD68 antibody, mast cells using anti-tryptase antibody, periglandular vascularization with the reaction using anti-CD34∕anti-CD31 antibodies, thus demonstrating their involvement in the development of adenomyosis.
|
31658314 |
2019 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unlike other solid tumours, high-density CD68+ macrophage infiltration can be a good prognostic marker for CRC.
|
31650222 |
2019 |
|
Stasis dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The presence of itch in SD was significantly associated with the amount of CD68(+)/IL-31(+) macrophages and CD68(+)/CD163(+) M2 macrophages.
|
31626785 |
2020 |